SS-31

SS-31 (Elamipretide; MTP-131) is a synthetic cell-permeable tetrapeptide developed by Hazel Szeto and Peter Schiller, featuring an alternating aromatic–cationic residue pattern — D-Arg-Dmt-Lys-Phe-NH₂ — where Dmt denotes 2′,6′-dimethyltyrosine. This motif enables selective accumulation at the inner mitochondrial membrane through electrostatic and hydrophobic interactions with cardiolipin (CL), an anionic phospholipid essential to electron transport chain organisation. SS-31 is a widely used tool compound in mitochondrial biology research for investigating cristae architecture, respiratory complex dynamics, and reactive oxygen species production.

Each vial arrives as lyophilized (freeze-dried) powder and must be reconstituted with bacteriostatic water before use in a research setting. Add the water slowly down the inside wall of the vial, then swirl gently until clear — never shake. Once reconstituted, keep it refrigerated and use within 28 days.

Sealed lyophilized vials are stable at ambient temperatures for 30 days and indefinitely at −20°C. After reconstitution, refrigerate at 2–8°C in the original vial and use within 28 days. Keep the vial out of direct light and avoid repeated temperature swings and agitation.

Quality and purity tests are performed on random batches, covering identity (mass spec), purity (HPLC) and endotoxin results.

Orders placed before 3:00 PM ET on a business day are typically shipped the same day, in plain, discreet packaging; transit is estimated at 2–4 business days.