Thymosin Alpha 1

Thymosin Alpha-1 (Tα1; Thymalfasin) is a 28-residue N-terminally acetylated polypeptide originally isolated from bovine thymus fraction 5 by Goldstein and Low in 1977. As the primary biologically active component of thymosin fraction 5, it is among the most studied immunomodulatory peptides in preclinical research, with proposed actions at Toll-like receptors (TLR2, TLR9) and downstream NF-κB/cytokine signalling pathways. Its sequence is fully conserved across human, mouse, rat, and bovine species, making it an important tool compound in cross-species immunological research models.

Each vial arrives as lyophilized (freeze-dried) powder and must be reconstituted with bacteriostatic water before use in a research setting. Add the water slowly down the inside wall of the vial, then swirl gently until clear — never shake. Once reconstituted, keep it refrigerated and use within 28 days.

Sealed lyophilized vials are stable at ambient temperatures for 30 days and indefinitely at −20°C. After reconstitution, refrigerate at 2–8°C in the original vial and use within 28 days. Keep the vial out of direct light and avoid repeated temperature swings and agitation.

Quality and purity tests are performed on random batches, covering identity (mass spec), purity (HPLC) and endotoxin results.

Orders placed before 3:00 PM ET on a business day are typically shipped the same day, in plain, discreet packaging; transit is estimated at 2–4 business days.